Insufficient telomerase activity, stemming from low telomerase reverse transcriptase (TERT) gene transcription, contributes to telomere dysfunction and aging pathologies. Besides its traditional function in telomere synthesis, TERT acts as a transcriptional co-regulator of genes pivotal in aging and age-associated diseases. Here, we report the identification of a TERT activator compound (TAC) that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC-induced elevation of TERT levels promotes telomere synthesis, blunts tissue aging hallmarks with reduced cellular senescence and inflammatory cytokines. In the brain, TAC alleviates neuroinflammation, increases neurotrophic factors, stimulates adult neurogenesis, and preserves cognitive function without evident toxicity, including cancer risk. Together, these findings underscore TERT’s critical role in aging processes and provide preclinical proof of concept for physiological TERT activation as a strategy to mitigate multiple aging hallmarks and associated pathologies.
Published in Cell June 22, 2024
"Consider utilizing the TERT gene frequency on the IMAET to resonate with that gene and upregulate it's activity into higher function. This may well be one of the better anti-aging strategies. Remember: imaet is good at upregulating gene function!
You'll find the TERT gene on the Allergens panel.
One could also imprint the TERT frequency into wearable technology such as our energy bracelets, for longer exposures and treatments." Dr. Bernard Straile
Straile: " We know with the IMAET we can upregulate
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