The trillions of microbes that reside in our intestines, collectively called the gut microbiome, are crucial for health. When balanced properly, these microbes aid digestion, synthesize vitamins (i.e. Vitamin K), regulate hormones, and strengthen immunity. However, when certain species overgrow, they can trigger inflammation and diseases like Crohn’s disease or ulcerative colitis. Research now shows that genetics influences our risk of microbial imbalances. Specifically, variants in the FUT2 gene impact which bacteria can thrive in our guts.
Around 20-25% of individuals of European descent possess a nonfunctional FUT2 gene variant. They are termed “non-secretors.” The FUT2 gene provides instructions for making an enzyme that builds sugar molecules on proteins lining the intestines. These sugar molecules act as food for beneficial gut microbes like Bifidobacterium. Without this enzyme, the intestinal environment becomes less hospitable for these favorable bacteria to flourish.
Studies reveal that non-secretors harbor lower microbial diversity and lower abundances of helpful Lactobacillus and Bifidobacterium species. They also possess more detrimental bacteria like Pseudomonas aeruginosa compared to secretors. Experts speculate that non-secretors’ altered intestinal environment allows inflammatory microorganisms to occupy excess space. This may partly explain links between non-secretor status and higher Crohn’s disease risk across multiple cohorts. Specifically, those homozygous for the rs601338 non-secretor variant show a 1.64 higher odds ratio for Crohn’s.
On the other hand, beneficial microbial products like short-chain fatty acids are key for intestinal barrier defense. Non-secretors’ deficits in useful microbes may impair short-chain fatty acid availability and weaken the gut lining. Researchers propose this could enable foreign material to leak out of the intestines (Leaky Gut) and trigger autoimmune responses underlying Crohn’s flares.
The good news: The IMAET Allergen Panel
and Biofield panel have FUT gene frequencies in their database to resonate with and potentially functionally upregulate these genes epigenetically. Consider adding FUT2 when working on Crohn's related issues and Gluten issues in general. Probably any inflammatory gut issue warrants a "visit" by this gene frequency or a tune-up of this gene.
Use SHOW Method type of treatment protocols to execute such treatments effectively.
Biofeld Panel:
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My personal FUT2 result below:
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